|
|
11-deoxycortisol + reduced_adrenodoxin + O2 + H+ <=> H2O + cortisol + oxidized_ferredoxin
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
M
|
|
BRENDA:
BS186773;
BS425303
MetaCyc:
RXN66-357
|
|
|
|
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 11-deoxycortisol + flavin + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
K
|
|
BRENDA:
BS427270
KEGG:
R03326
|
|
|
|
11-deoxycortisol + 2 reduced_ferredoxin + O2 + 2 H+ <=> cortisol + 2 oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
K
|
|
KEGG:
R02843
|
|
|
|
11-deoxycortisol + H+ + NADH <=> 17alpha,21-Dihydroxypregnenolone + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
|
K
|
|
KEGG:
R04849
|
|
|
|
17alpha-hydroxyprogesterone + reduced_adrenodoxin + O2 + H+ <=> 11-deoxycortisol + oxidized_ferredoxin + H2O
|
1.14.15
|
–
|
M
|
|
MetaCyc:
RXN66-356
|
|
|
|
11-deoxycortisol + adrenal_ferredoxin + H2O <=> cortisol + reduced_ferredoxin + O2
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS394618
|
|
|
|
17alpha-hydroxyprogesterone + [reduced_NADPH-P450_reductase] + O2 <=> 11-deoxycortisol + [oxidized_NADPH-P450_reductase] + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS427271
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> 4-Pregnene-11,17,21-triol-3,20-dione + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS186772
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> 14alpha,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS186774
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> 14alpha-hydroxy-11-deoxycortisol + oxidized_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS186787
|
|
|
|
17alpha-hydroxyprogesterone + reduced_acceptor + O2 <=> 11-deoxycortisol + A + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS403311
|
|
|
|
17alpha-hydroxyprogesterone + NADH + O2 <=> 11-deoxycortisol + NAD+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186797
|
|
|
|
17-hydroxy-pregn-4-ene-3,20,21-trione + NADH <=> 11-deoxycortisol + NAD+
|
1.1.1.150
21-hydroxysteroid dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BS187297
|
|
|
|
11-deoxycortisol + reduced_adrenodoxin + O2 <=> 15beta-15,17,21-trihydroxypregn-4-ene-3,20-dione + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS403302
|
|
|
|
17alpha-hydroxyprogesterone + NADPH + O2 <=> 11-deoxycortisol + NADP+ + H2O
|
1.14.14.16
steroid 21-monooxygenase
|
–
|
|
|
BRENDA:
BS186803
|
|
|
|
17-hydroxy-pregn-4-ene-3,20,21-trione + NADPH <=> 11-deoxycortisol + NADP+
|
1.1.1.151
21-hydroxysteroid dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS187305
|
|
|
|
11-deoxycortisol + NADPH <=> 17,21-Dihydroxy-5alpha-pregnan-3,20-dione + NADP+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS260959
|
|
|
|
11-deoxycortisol + NADPH <=> 17alpha,21-dihydroxy-pregnan-3,20-dione + NADP+
|
1.3.1.3
Delta4-3-oxosteroid 5beta-reductase
|
–
|
|
|
BRENDA:
BS258422
|
|
|
|
11-deoxycortisol + NADPH + O2 <=> cortisol + NADP+ + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS387040
|
|
|
|
11-deoxycortisol + NADPH <=> 17,21-Dihydroxy-5alpha-pregnan-3,20-dione
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS258531
|
|
|
|
11-deoxycortisol <=> 17alpha,20-Dihydroxy-3-oxopregn-4-en-21-al
|
5.3.1.21
corticosteroid side-chain-isomerase
|
–
|
|
|
BRENDA:
BS1037
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> cortisol + Ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS386036
|
|
|
|
11-deoxycortisol + reduced_ferredoxin + O2 <=> cortisol + adrenal_ferredoxin + H2O
|
1.14.15.4
steroid 11beta-monooxygenase
|
–
|
|
|
BRENDA:
BS386037
|
|
|
|
11-deoxycortisol + acceptor <=> 1,4-Pregnene-17alpha,21-diol-3,20-dione + reduced_acceptor
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
|
BRENDA:
BS258856
|
|